13+ Isekai Anime With
Female MC (MUST WATCH)

Isekai anime has simply dominated the anime industry for a long time now. Ever since the release of Sword Art Online, more and more isekai have been released, sometimes multiple every season. That doesn’t mean that there weren’t any from this genre before SAO, but they were likely forgotten over time. 

But what are we still lacking after all these years? Female leads! Of course, there were plenty of girl deuteragonists, but they didn’t take control of the show. I believe it is a completely different matter to write isekai from other genres, and most of the popular settings of the scene are just not fitting for female protagonists.

Here, I gathered fifteen anime for the fans of specific tags. Although this surely doesn’t sound exotic, there are actually just a few of this kind. Now sit back and read through our top picks for female leads!

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Genre: Isekai
Isekai Genre
Genre info

Isekai is currently the most popular genre of anime. In every anime season in the past couple of years, there have always been a handful of Isekai titles.

Isekai anime is essentially where a character or a group of characters get transported or reincarnated in another world.

Table of Content

15. The Twelve Kingdoms

Studio Pierrot is known for their long-running shonen anime, and especially their ability to keep releasing new episodes every week – sometimes for multiple shows at the same time! The Twelve Kingdom was one of their early works, so let’s take a look at it!

The studious, but shy Youko was always a pushover in her class. One day a blond prince showed up and announced that Youko is a noble, and she should assume the throne of his world. She and two of her classmates are taken to that world in a hurry, and they quickly find themselves in trouble! 

If I were suddenly told that I was a noble, heck! I’d pack my bags and go in a flash.

14. Restaurant to Another World

Restaurant To Another World

Imagine going to a new place to eat, and you immediately fall in love with the eatery. You want to visit it on the weekend again, but it is closed on Saturdays. You might get pretty mad about it, and then make a quick decision to take a sneak peek from the back. That’s the point your jaw drops.

In this wonderful restaurant, a portal opens every Saturday, and different mythical creatures then appear. But hey, they only came here for the food! The chef is amazing, and the staff easily keeps up the mood. A great anime to watch for sure!

13. Ascendance of a Bookworm

Ascendance of a bookworm

Do you like reading books? Well, I don’t, but the protagonist in this show lives for reading. She didn’t live for long though. 

After reincarnating in Medieval Europe as a five-year-old, Myne started searching for an opportunity to read something. As the printing press didn’t exist yet, and hand-written books were quite expensive, she had a hard time fulfilling her passion. Can she ever solve this dire crisis?

12. My Next Life as a Villainess: All Routes Lead to Doom!

My Next Life As A Villainess

There are plenty of other variations for the title of this show, but I don’t want to share any, as they are even longer than this one. Let’s call it simply Hamefura for now, as everyone else does too.

This anime came out last year, but I don’t remember seeing much hype around it. This is weird, as the concept is interesting! Have you ever dreamed of living in your favorite game? Catarina managed to achieve that, but she became the main antagonist of the world. Not so lucky, heh.

11. Kakuriyo: Bed and Breakfast for Spirits

Kakuriyo

If Food Wars wasn’t enough, then take a look at this anime about an isekai-d girl opening a small-scale restaurant inside a tavern. Aoi was able to see the spirits called Ayakashi from a young age, and her grandpa taught her to live peacefully with them.

After feeding a spirit out of pure kindness, she was taken by that certain ayakashi to another world, where he revealed himself to be an ogre god. He also asked Aoi to marry him so she can clear the insane debt her grandpa had to this spirit. She politely declined and worked her way through as a chef to pay everything back.

10. Vision of Escaflowne

Sunrise Studio really is in love with mechas. Their finest works include Code Geass and pieces of Gundam, but they started their career with hits like Cowboy Bebop, and Vision of Escaflowne too. 

The latter isn’t nearly as good but still has some interesting qualities. The historical and magical setting spiced up with robots is a big bowl of pleasure. Taken in by a pillar of light, Hitomi has to work together with the prince of the land, Van, to counter the invading forces of an enemy nation.

9. Bofuri: I Don't Want To Get Hurt, So I'll Max Out My Defense

Bofuri

Now we enter the realm of obnoxiously long titles. Almost every isekai is being titled like this nowadays, and to be honest the sharp explanations really make it easy to differentiate similar shows.

What can we say about Bofuri then? People like to compare it to The Rising of The Shield Hero, mostly because it also features a min-max build with a shield. But hold on, Bofuri actually features realistic MMO elements! While the overall quality is questionable, it is surely enjoyable.

8. Fushigi Yuugi

Miaka and Yui were just chilling in the library when they were swallowed by a book set in Ancient China. The former best friends are now mortal enemies: they became the priestesses of rival nations. With plenty of things to take care of, their friendship is nearly lost.

7. Magic Knight Rayearth

Released in the 90s, Rayearth has a pretty interesting art style. Not just with the standards of the time, but it’s very easy to differentiate it from anything else, mostly due to the vibrating colors and thick lines.

The protagonist in this case wasn’t hit by a truck, but she was swept away by a giant flying fish. This was just the cover-up of a rally from another world. The girls are asked to be the heroes they need, and they comply with ambitions.

6. I've Been Killing Slimes For 300 Years And Maxed Out My Level

Have you ever watched South Park? I’m pretty sure that one of your favorite episodes was the one including World of Warcraft. It was just the finest comedy fitting perfectly for the target audience. This anime with a lengthy title is actually quite similar to that SP episode.

Just like Cartman and the boys did with boars, the protagonist, Azusa, farmed low-level monsters to gain experience. She took out slimes for 300 years and reached the max level. But what can an introvert like her do after all that? Many other adventurers came to her house, either to fight or to find company. Now her life is more than busy!

5. So I'm A Spider, So What?

So I'm A Spider So What

Yes, this title would be crossed out in an instant if the line appeared in a high school English essay. On the other hand, the content will easily win an A+ if presented. What’s up with transforming into slimes, spiders, and such creatures in anime nowadays?

In this show, there was a massive reincarnation wave hitting the student body of a school that suffered a catastrophe. They all started a new life as various species, but the protagonist girl managed to become a spider. Drawing the weakest card didn’t stop her though!

4. InuYasha

Inuyasha

InuYasha is more than a classic for many fans. It didn’t make it into the big three, but the legacy of this early 2000s anime is still keeping up. 

Quite a harsh start for a shonen/isekai, but Kagome didn’t get hit by a truck this time. She was dragged down into a well by a demon, and after that, she woke up almost 500 years in the past in feudal Japan. Also, a powerful item, the Shikon Jewel is reborn inside her too.

Thus, she became the target of demons. Soon the jewel shattered, and she teamed up with the half-demon Inuyasha to collect the shards of this gem.

3. Spirited Away

Spirited Away

Spirited Away has quite a reputation as the only anime movie ever to win an Oscar. Studio Ghibli is probably the most well-known Japanese animation studio in the West, and for a reason. They have plenty of experience in the field, and Spirited Away might be their best work. 

The story of Chihiro being forced into a ghost world is both frightening and philosophical, but it also warms the heart. Was the black-masked guy your favorite character as well? Yea, it’s not even a question. I wish we could have seen a little more development on his side though.

2. Saga of Tanya the Evil

Saga of Tanya The Evil

Sometimes the translators like to have a little fun with the titles. The original Japanese title of this show is Youjo Senki. Now as you can see, it has nothing to do with Tanya. The other widely accepted title is The Military Chronicles of a Little Girl or War Diary for short – the latter derives from the Spanish title, Diario de Guerra.

The ruthless military genius, Tanya was brought to the world of magical warfare by a being named Existence X. As punishment, X also turned the full-grown man into a little girl. Yes, Tanya was a man. 

Now she wants to create a peaceful life in a war-torn world, of course with the means of violence. She quickly rose in ranks, and now the world would crumble if she were to make a move.

1. No Game No Life

No Game No Life

Second season when? Short answer: probably never.

It’s hard to tell that Madhouse made this anime, but they proved their abilities in the comedy genre with One Punch Man too. No Game No Life is a pretty surreal comedy, revolving entirely around the strategic and tactical moves of the main characters. 

To challenge the god of games, Shiro and Sora mostly rely on their intellects. The siblings are quick-witted and sneaky in their playstyle, just like when they played as a duo in online games.

 

Conclusion

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Did you like our entries? It is quite hard to rank anime so similar in quality, so we are curious about your rankings too! Send us your top five in the comments down below! And also make sure to check out our other articles about the isekai genre.

Make sure to comment or Imma hit you so hard you’ll get reincarnated in another world!

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